Chilli (Capsicum annuum L.), an essential agricultural commoditycharacterized byits abundance of vitamins and antioxidants, is subjected to considerable productivityimpediments attributed to viral pathogens, notably the chilli leaf curl virus (ChiLCV). The exacerbation of these infections through vector-mediated transmission culminates in substantial agricultural yield reductions, thereby underscoring the imperative for the implementation of sustainable management methodologies. The current investigation delves into the contributionsofrhizobacterial isolates and Arbuscular Mycorrhizal (AM) fungi in the enhancement of chilli plant vigour, bolstering resistance to viral afflictions and augmenting overall yield. The research assessed a microbial consortium consisting of Streptomyces rimosus AUDT 502 + Streptomyces hyderabadensis DBT64 + Pseudomonas marginalis AUDP279 + Glomus fasciculatum. Specimens subjected to treatment with the consortium exhibited pronounced improvements in critical growth parameters, including an 89 per cent augmentation in height at 30 days post-sowing (DAS) and a 60.34 per cent elevation in chlorophyll content at 30 days subsequent to transplantation (DAT). The disease severity index experienced a diminution of 80 per cent at 15 days following inoculation (DAI) and a reduction of 68.18 per cent at 30 DAI, thereby validating the consortium's efficacy in disease mitigation. Transcriptomic evaluations further substantiated these observations, revealing that the treated plants exhibited upregulation of defense-associated genes implicated in MAPK signaling, RNA silencing and secondary metabolite pathways. The consortium's capacity to modulatetranscriptomicpathways,improvephysiologicalhealthandmitigatediseaseseverity positions it as a promising strategy for the sustainable cultivation of chilli. These findings illuminatethepotentialofbiotechnologicalinterventionsofthisnaturetoalleviatecropstress, ensure plant vitality and amplify yields, thereby contributing to a robust framework for integrated pest and disease management.